Which of the following is an example of Multifactorial inheritance?

Multifactorial inheritance refers to traits and conditions that are influenced by multiple genes (polygenic inheritance) and environmental factors. An example of this is cleft palate, which typically results from a combination of genetic predispositions and environmental triggers such as maternal nutrition, medications, or exposure to certain substances during pregnancy.

In contrast, conditions like Down syndrome result from chromosomal abnormalities (specifically trisomy 21) rather than multifactorial influences. Huntington's disease is a single-gene disorder caused by mutations in the HTT gene, which follows Mendelian inheritance patterns. Achondroplasia is also a single-gene disorder caused by mutations in the FGFR3 gene, which again does not involve multifactorial inheritance.

Therefore, cleft palate exemplifies multifactorial inheritance because it arises from a complex interplay of genetic and environmental factors, distinguishing it from the other options that are associated with single-gene disorders or chromosomal aberrations.